Prostate adenoma is the most common benign tumor affecting almost 40 percent of older men. Symptoms associated with prostate adenoma are known as lower urinary tract symptoms, which cause great anxiety, significantly affect the life of men.
Drug treatment for prostate adenoma currently includes two classes of drugs:
Alpha-adrenergic receptor blockers (Hytrin, Cardura, Flomax), including certain agents of Alfuzosin and Tamsulosin
Originally used to treat high blood pressure, Cardura and Hytrin reduce smooth muscle tissue around the blood vessels and in the prostate and bladder areas. The use of all three drugs, as studies have shown, helps to increase the urinary flow, greatly alleviate the irritating effects. They act on the process immediately.
Side effects: low blood pressure, causing dizziness, fatigue, headaches, ejaculatory dysfunction, orthostatic hypotension. To minimize side effects, the dose in treatment is increased gradually. For example, for Hytrin - from 1 mg / day to 2 mg / day and so to 5 mg / day. The first reception, as a rule, before a night rest.
Flomax is an alpha-adrenergic receptor blocker that is more specific for the prostate and has fewer side effects, but it also has less effect on blood vessels and blood pressure, so it is considered less effective than the above. However, the advantage of treating with flomax is that there is no need to increase the dose gradually, starting with the most effective dose (0.8 mg / day).
5-alpha-reductase inhibitors (Dutasteride and Finasteride), representing the second class of drugs in the drug treatment of prostate adenoma, were developed in such a way as to reduce symptoms that prevent the passage of the urinary tract.
The agents act by inhibiting the enzyme, which converts testosterone into a more active form - dihydrotestosterone, which is responsible for enlarging the prostate.
Treatment with 5-alpha reductase inhibitors is slow at the initial stage, it can take up to six weeks until the effect occurs, but they really delay the progression of prostate adenoma.
Two currently available agents from this group are Dutasteride and Finasteride.
Side effects are associated, first of all, with a decreased volume of ejaculate and a decrease in libido.